Open AccessMajor Adverse Cardiovascular Events During Invasive Pneumococcal Disease Are Serotype Dependent
Author(s) -
Hector F Africano,
Cristian C. Serrano-Mayorga,
Paula C. Ramirez-Valbuena,
Ingrid G. Bustos,
Alirio Bastidas,
Hernán Vargas,
Sandra Patricia Montenegro Gómez,
Alejandro Rodríguez,
Carlos J. Orihuela,
Luis Felipe Reyes
Publication year - 2020
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa1427
Subject(s) - mace , medicine , bacteremia , retrospective cohort study , streptococcus pneumoniae , serotype , myocardial infarction , odds ratio , community acquired pneumonia , acute coronary syndrome , cohort , pneumonia , immunology , percutaneous coronary intervention , microbiology and biotechnology , antibiotics , biology
Up to 30% of patients admitted to hospitals with invasive pneumococcal disease (IPD) experience major adverse cardiovascular event (MACE) including new/worsening heart failure, new/worsening arrhythmia, and/or myocardial infarction. Streptococcus pneumoniae (Spn) is the most frequently isolated bacterial pathogen among community-acquired pneumonia (CAP) patients and the only etiological agent linked independently to MACE. Nevertheless, no clinical data exist identifying which serotypes of Spn are principally responsible for MACE.