Open AccessDNA Methylation and Immune Cell Markers Demonstrate Evidence of Accelerated Aging in Patients with Chronic Hepatitis B Virus or Hepatitis C Virus, with or without Human Immunodeficienct Virus Co-infection
Author(s) -
Yevgeniy Gindin,
Anuj Gaggar,
Anna S. Lok,
Harry L.A. Janssen,
Carlo Ferrari,
G. Mani Subramanian,
Zhaoshi Jiang,
Henry Masur,
Benjamin Emmanuel,
Bhawna Poonia,
Shyam Kottilil
Publication year - 2020
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa1371
Subject(s) - medicine , immunology , immune system , hepatitis b virus , viral load , dna methylation , hepatitis c virus , virus , epigenetics , hepatitis b , virology , biology , genetics , gene expression , gene
Several chronic diseases accelerate biological aging. We investigated age acceleration and the association between peripheral blood DNA methylation (DNAm) and immune cell markers in patients chronically infected with the hepatitis B virus (HBV) or the hepatitis C virus (HCV) with and without human immunodeficiency virus (HIV) co-infection.