Temporal, Spatial, and Epidemiologic Relationships of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Gene Cycle Thresholds: A Pragmatic Ambi-directional Observation | Zendy

Emil Lesho | Zendy; Lisa Reno | Zendy; Donewhart | Zendy; Robert Clifford | Zendy; Olga Vasylyeva | Zendy; John Hanna | Zendy; Stephanie Yu | Zendy; Jonathan Bress | Zendy; Edward E. Walsh | Zendy

Open Access

Temporal, Spatial, and Epidemiologic Relationships of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Gene Cycle Thresholds: A Pragmatic Ambi-directional Observation

Author(s) -

Emil Lesho,

Lisa Reno,

Donewhart,

Robert Clifford,

Olga Vasylyeva,

John Hanna,

Stephanie Yu,

Jonathan Bress,

Edward E. Walsh

Publication year - 2020

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciaa1248

Subject(s) - covid-19 , virology , coronavirus , betacoronavirus , respiratory system , gene , medicine , biology , genetics , pathology , outbreak , disease , infectious disease (medical specialty)

Prospective serial sampling of 70 patients revealed clinically relevant cycle thresholds (Ct) occurring 9, 26, and 36 days after symptom onset. Race, gender, and corticosteroids apparently did not influence RNA positivity. In a retrospective analysis of 180 patients, initial Ct did not correlate with requirements for admission or intensive care.

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