Mucosal-associated invariant T cells are activated in an interleukin-18-dependent manner in Epstein–Barr virus-associated T/natural killer cell lymphoproliferative diseases | Zendy

Yuriko Ishikawa | Zendy; Masaki Yamada | Zendy; Naomi Wada | Zendy; Etsuko Takahashi | Zendy; KenIchi Imadome | Zendy

Open Access

Mucosal-associated invariant T cells are activated in an interleukin-18-dependent manner in Epstein–Barr virus-associated T/natural killer cell lymphoproliferative diseases

Author(s) -

Yuriko Ishikawa,

Masaki Yamada,

Naomi Wada,

Etsuko Takahashi,

KenIchi Imadome

Publication year - 2022

Publication title -

clinical and experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1093/cei/uxab004

Subject(s) - immunology , natural killer t cell , virus , lymphoproliferative disorders , natural killer cell , epstein–barr virus , interleukin 15 , lymphoproliferative response , biology , virology , interleukin , immune system , t cell , cytokine , lymphoma , cytotoxic t cell , in vitro , peripheral blood mononuclear cell , biochemistry

Mucosal-associated invariant T (MAIT) cells are a type of innate immune cells that protect against some infections. However, the involvement of MAIT cells in Epstein–Barr virus-associated T/natural killer cell lymphoproliferative diseases (EBV-T/NK-LPD) is unclear. In this study, we found that MAIT cells were highly activated in the blood of patients with EBV-T/NK-LPD. MAIT cell activation levels correlated with disease severity and plasma IL-18 levels. Stimulation of healthy peripheral blood mononuclear cells with EBV resulted in activation of MAIT cells, and this activation level was enhanced by exogenous IL-18. MAIT cells stimulated by IL-18 might thus be involved in the immunopathogenesis of EBV-T/NK-LPD.

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