Open AccessCrosstalk between gut microbiota and sepsis
Author(s) -
Mengwei Niu,
Peng Chen
Publication year - 2021
Publication title -
burns and trauma
Language(s) - English
Resource type - Journals
ISSN - 2321-3876
DOI - 10.1093/burnst/tkab036
Subject(s) - sepsis , crosstalk , gut flora , microbiome , immunology , immune system , fecal bacteriotherapy , gut microbiome , biology , transplantation , disease , immunity , medicine , bioinformatics , antibiotics , microbiology and biotechnology , clostridium difficile , physics , optics
Sepsis is an overwhelming inflammatory response to microbial infection. Sepsis management remains a clinical challenge. The role of the gut microbiome in sepsis has gained some attention. Recent evidence has demonstrated that gut microbiota regulate host physiological homeostasis mediators, including the immune system, gut barrier function and disease susceptibility pathways. Therefore, maintenance or restoration of microbiota and metabolite composition might be a therapeutic or prophylactic target against critical illness. Fecal microbiota transplantation and supplementation of probiotics are microbiota-based treatment methods that are somewhat limited in terms of evidence-based efficacy. This review focuses on the importance of the crosstalk between the gastrointestinal ecosystem and sepsis to highlight novel microbiota-targeted therapies to improve the outcomes of sepsis treatment.