Open AccessResolution of pathogenic R-loops rescues motor neuron degeneration in spinal muscular atrophy
Author(s) -
Niko Hensel,
Nora Tula Detering,
Lisa Walter,
Peter Claus
Publication year - 2019
Publication title -
brain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.142
H-Index - 336
eISSN - 1460-2156
pISSN - 0006-8950
DOI - 10.1093/brain/awz394
Subject(s) - spinal muscular atrophy , motor neuron , degeneration (medical) , neuroscience , atrophy , amyotrophic lateral sclerosis , biology , medicine , anatomy , spinal cord , pathology , disease
This scientific commentary refers to ‘ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy’, by Kannan et al. (doi: 10.1093/brain/awz373).
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