Hitting the brakes: pathological subthalamic nucleus activity in Parkinson’s disease gait freezing | Zendy

Matthew J. Georgiades | Zendy; James M. Shine | Zendy; Moran Gilat | Zendy; Jacqueline McMaster | Zendy; Brian Owler | Zendy; Neil Mahant | Zendy; Simon J.G. Lewis | Zendy

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Hitting the brakes: pathological subthalamic nucleus activity in Parkinson’s disease gait freezing

Author(s) -

Matthew J. Georgiades,

James M. Shine,

Moran Gilat,

Jacqueline McMaster,

Brian Owler,

Neil Mahant,

Simon J.G. Lewis

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz325

Subject(s) - subthalamic nucleus , parkinson's disease , pathological , gait , neuroscience , disease , deep brain stimulation , physical medicine and rehabilitation , psychology , medicine , pathology

The neurobiology of gait freezing in Parkinson’s disease is poorly understood and therapies are largely ineffective. Using a virtual reality task to elicit freezing intra-operatively during implantation of DBS electrodes, Georgiades et al. identify pathological subthalamic nucleus activity associated with freezing onset and discernible from that of volitional stopping.

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