Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts | Zendy

Shen Li | Zendy; Byoung Chol Oh | Zendy; Chengyan Chu | Zendy; Antje Arnold | Zendy; Anna Jabłońska | Zendy; Georg J. Furtmüller | Zendy; Huamin Qin | Zendy; Johannes Boltze | Zendy; Tim Magnus | Zendy; Peter Ludewig | Zendy; Mirosław Janowski | Zendy; Gerald Brandacher | Zendy; Piotr Walczak | Zendy

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Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts

Author(s) -

Shen Li,

Byoung Chol Oh,

Chengyan Chu,

Antje Arnold,

Anna Jabłońska,

Georg J. Furtmüller,

Huamin Qin,

Johannes Boltze,

Tim Magnus,

Peter Ludewig,

Mirosław Janowski,

Gerald Brandacher,

Piotr Walczak

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz275

Subject(s) - progenitor cell , context (archaeology) , transplantation , blockade , progenitor , immunology , biology , stem cell , stimulation , neuroscience , cd154 , medicine , cytotoxic t cell , microbiology and biotechnology , cd40 , in vitro , receptor , biochemistry , paleontology

White matter repair through transplantation of allogeneic glial progenitors is now feasible in immune-deficient animals, but the immunological barrier precludes its clinical translation. Li et al. develop a strategy based on co-stimulation blockade that induces immunological hyporesponsiveness and supports long-term functionality of allotransplanted myelinating oligodendrocytes.

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