Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson’s disease | Zendy

Mingli Li | Zendy; HuaDong Xu | Zendy; Guoqing Chen | Zendy; Suhua Sun | Zendy; Qinglong Wang | Zendy; Bing Liu | Zendy; Xi Wu | Zendy; Li Zhou | Zendy; Zuying Chai | Zendy; Xiaoxuan Sun | Zendy; Yang Lu | Zendy; Muhammad Younus | Zendy; Lianghong Zheng | Zendy; Feipeng Zhu | Zendy; Hongbo Jia | Zendy; Xiaowei Chen | Zendy; Changhe Wang | Zendy; Zhuan Zhou | Zendy

Open Access

Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson’s disease

Author(s) -

Mingli Li,

HuaDong Xu,

Guoqing Chen,

Suhua Sun,

Qinglong Wang,

Bing Liu,

Xi Wu,

Li Zhou,

Zuying Chai,

Xiaoxuan Sun,

Yang Lu,

Muhammad Younus,

Lianghong Zheng,

Feipeng Zhu,

Hongbo Jia,

Xiaowei Chen,

Changhe Wang,

Zhuan Zhou

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz243

Subject(s) - neuroscience , dopaminergic , prefrontal cortex , parkinson's disease , psychology , disease , dopamine receptor d2 , dopamine , medicine , cognition

Anxiety is a major early-onset non-motor symptom in Parkinson’s disease, but the underlying mechanisms remain largely unknown. By imaging brain circuits in an awake parkinsonian mouse model, Li, Xu et al. provide evidence that Parkinson’s disease-associated anxiety is caused by impaired postsynaptic D2 receptor-dependent dopaminergic transmission in prefrontal cortex.

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