Deep brain stimulation induced normalization of the human functional connectome in Parkinson’s disease | Zendy

Andreas Horn | Zendy; Gregor Wenzel | Zendy; Friederike Irmen | Zendy; Julius Huebl | Zendy; Ningfei Li | Zendy; WolfJulian Neumann | Zendy; Patricia Krause | Zendy; Georg Böhner | Zendy; Michael Scheel | Zendy; Andrea A. Kühn | Zendy

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Deep brain stimulation induced normalization of the human functional connectome in Parkinson’s disease

Author(s) -

Andreas Horn,

Gregor Wenzel,

Friederike Irmen,

Julius Huebl,

Ningfei Li,

WolfJulian Neumann,

Patricia Krause,

Georg Böhner,

Michael Scheel,

Andrea A. Kühn

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz239

Subject(s) - deep brain stimulation , neuroscience , subthalamic nucleus , connectome , stimulation , parkinson's disease , functional connectivity , brain stimulation , psychology , medicine , disease , pathology

Deep brain stimulation has local effects on the target structure, but also global effects via distributed brain networks. Horn et al. show that modulating the activity of the subthalamic nucleus in patients with Parkinson’s disease normalizes signatures of widespread network connectivity towards those found in healthy controls.

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