Genome-wide association study of cerebral small vessel disease reveals established and novel loci | Zendy

Jaeyoon Chung | Zendy; Sandro Marini | Zendy; Joanna Pera | Zendy; Bo Norrving | Zendy; Jordi Jiménez-Conde | Zendy; Jaume Roquer | Zendy; Israel FernándezCadenas | Zendy; David Tirschwell | Zendy; Magdy Selim | Zendy; Devin L. Brown | Zendy; Scott Silliman | Zendy; Bradford B. Worrall | Zendy; James F. Meschia | Zendy; Stacie L Demel | Zendy; Steven M. Greenberg | Zendy; Agnieszka Słowik | Zendy; Cecilia M. Lindgren | Zendy; Reinhold Schmidt | Zendy; Matthew Traylor | Zendy; Muralidharan Sargurupremraj | Zendy; Steffen Tiedt | Zendy; Rainer Malik | Zendy; Stéphanie Debette | Zendy; Martin Dichgans | Zendy; Carl D. Langefeld | Zendy; Daniel Woo | Zendy; Jonathan Rosand | Zendy; Christopher D. Anderson | Zendy

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Genome-wide association study of cerebral small vessel disease reveals established and novel loci

Author(s) -

Jaeyoon Chung,

Sandro Marini,

Joanna Pera,

Bo Norrving,

Jordi Jiménez-Conde,

Jaume Roquer,

Israel FernándezCadenas,

David Tirschwell,

Magdy Selim,

Devin L. Brown,

Scott Silliman,

Bradford B. Worrall,

James F. Meschia,

Stacie L Demel,

Steven M. Greenberg,

Agnieszka Słowik,

Cecilia M. Lindgren,

Reinhold Schmidt,

Matthew Traylor,

Muralidharan Sargurupremraj,

Steffen Tiedt,

Rainer Malik,

Stéphanie Debette,

Martin Dichgans,

Carl D. Langefeld,

Daniel Woo,

Jonathan Rosand,

Christopher D. Anderson

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz233

Subject(s) - phenotype , genome wide association study , disease , locus (genetics) , intracerebral hemorrhage , stroke (engine) , genetic association , genetics , medicine , biology , pathology , gene , genotype , single nucleotide polymorphism , mechanical engineering , subarachnoid hemorrhage , engineering

Intracerebral haemorrhage (ICH) and small vessel ischaemic stroke (SVS) are the most severe manifestations of cerebral small vessel disease. In a cross-phenotype genome-wide association analysis, Chung et al. identify two novel associations at 2q33 and 13q34 plus a previously identified locus at 1q22 for non-lobar ICH and SVS risk.

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