Open AccessClinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease
Author(s) -
Jonathan Vöglein,
Katrina L. Paumier,
Mathias Jucker,
Oliver Preische,
Eric McDade,
Jason Hassenstab,
Tammie L.S. Benzinger,
James M. Noble,
Sarah Berman,
Neill R. GraffRadford,
Bernardino Ghetti,
Martin R. Farlow,
Jasmeer P. Chhatwal,
Stephen Salloway,
Chengjie Xiong,
Celeste M. Karch,
Nigel J. Cairns,
Hiroshi Mori,
Peter R. Schofield,
Colin L. Masters,
Alison Goate,
Virginia Buckles,
Nick C. Fox,
Martin N. Rossor,
Patricio Chrem,
Ricardo Allegri,
John M. Ringman,
Günter U. Höglinger,
Harald Steiner,
Marianne Dieterich,
Christian Haass,
Christoph Laske,
John C. Morris,
Randall J. Bateman,
Adrian Danek,
Johannes Levin
Publication year - 2019
Publication title -
brain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.142
H-Index - 336
eISSN - 1460-2156
pISSN - 0006-8950
DOI - 10.1093/brain/awz050
Subject(s) - basal ganglia , presenilin , disease , motor symptoms , pathophysiology , neuroscience , degenerative disease , alzheimer's disease , medicine , pathology , psychology , central nervous system , parkinson's disease
Aβ deposition in the basal ganglia is common in autosomal dominant Alzheimer’s disease. Vöglein et al. report an increased severity of motor symptoms in autosomal dominant versus sporadic disease in advanced disease stages. Motor symptoms are more severe in post-codon 200 presenilin 1 mutation carriers and correlate with basal ganglia Aβ.
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