The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction | Zendy

Felix Chan | Zendy; Nichola Z. Lax | Zendy; Caroline M. Voss | Zendy; Blanca I. Aldana | Zendy; Shuna Whyte | Zendy; Alistair Jenkins | Zendy; Claire Nicholson | Zendy; Sophie Nichols | Zendy; Elizabeth Tilley | Zendy; Zoe Powell | Zendy; Helle S. Waagepetersen | Zendy; Ceri H. Davies | Zendy; Douglass M. Turnbull | Zendy; Mark O. Cunningham | Zendy

Open Access

The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction

Author(s) -

Felix Chan,

Nichola Z. Lax,

Caroline M. Voss,

Blanca I. Aldana,

Shuna Whyte,

Alistair Jenkins,

Claire Nicholson,

Sophie Nichols,

Elizabeth Tilley,

Zoe Powell,

Helle S. Waagepetersen,

Ceri H. Davies,

Douglass M. Turnbull,

Mark O. Cunningham

Publication year - 2018

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awy320

Subject(s) - epilepsy , neuroscience , glutamate receptor , gabaergic , mitochondrial disease , mitochondrion , epileptogenesis , mitochondrial respiratory chain , glutamine , biology , medicine , inhibitory postsynaptic potential , mitochondrial dna , microbiology and biotechnology , biochemistry , receptor , amino acid , gene

Many patients with mitochondrial disease have neurological symptoms, including drug-refractory epilepsy. Chan et al. develop an in vitro model of mitochondrial epilepsy with face and predictive validity. The model provides mechanistic insights into the role of astrocytes and the GABA-glutamate-glutamine cycle in driving seizure generation.

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