TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF | Zendy

Jin Han Nam | Zendy; Eun Su Park | Zendy; So-Yoon Won | Zendy; Yu A. Lee | Zendy; Kyoung I. Kim | Zendy; Jae Yeong Jeong | Zendy; Jeong Yeob Baek | Zendy; Eun J. Cho | Zendy; Minyoung Jin | Zendy; Young Cheul Chung | Zendy; Byoung D. Lee | Zendy; Sung Hyun Kim | Zendy; EungGook Kim | Zendy; Kyunghee Byun | Zendy; BongHee Lee | Zendy; Dong Ho Woo | Zendy; C. Justin Lee | Zendy; Sang Ryong Kim | Zendy; Eugene Bok | Zendy; Yoon-Seong Kim | Zendy; TaeBeom Ahn | Zendy; Hyuk Wan Ko | Zendy; Saurav Brahmachari | Zendy; Olga Pletinkova | Zendy; Juan C. Troconso | Zendy; Valina L. Dawson | Zendy; Ted M. Dawson | Zendy; Byung Kwan Jin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF

Author(s) -

Jin Han Nam,

Eun Su Park,

So-Yoon Won,

Yu A. Lee,

Kyoung I. Kim,

Jae Yeong Jeong,

Jeong Yeob Baek,

Eun J. Cho,

Minyoung Jin,

Young Cheul Chung,

Byoung D. Lee,

Sung Hyun Kim,

EungGook Kim,

Kyunghee Byun,

BongHee Lee,

Dong Ho Woo,

C. Justin Lee,

Sang Ryong Kim,

Eugene Bok,

Yoon-Seong Kim,

TaeBeom Ahn,

Hyuk Wan Ko,

Saurav Brahmachari,

Olga Pletinkova,

Juan C. Troconso,

Valina L. Dawson,

Ted M. Dawson,

Byung Kwan Jin

Publication year - 2015

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awv297

Subject(s) - substantia nigra , neuroprotection , ciliary neurotrophic factor , dopamine , neuroscience , parkinson's disease , pars compacta , trpv1 , medicine , neurotrophic factors , biology , dopaminergic , receptor , transient receptor potential channel , disease

Currently there is no neuroprotective or neurorestorative therapy for Parkinson's disease. Here we report that transient receptor potential vanilloid 1 (TRPV1) on astrocytes mediates endogenous production of ciliary neurotrophic factor (CNTF), which prevents the active degeneration of dopamine neurons and leads to behavioural recovery through CNTF receptor alpha (CNTFRα) on nigral dopamine neurons in both the MPP(+)-lesioned or adeno-associated virus α-synuclein rat models of Parkinson's disease. Western blot and immunohistochemical analysis of human post-mortem substantia nigra from Parkinson's disease suggests that this endogenous neuroprotective system (TRPV1 and CNTF on astrocytes, and CNTFRα on dopamine neurons) might have relevance to human Parkinson's disease. Our results suggest that activation of astrocytic TRPV1 activates endogenous neuroprotective machinery in vivo and that it is a novel therapeutic target for the treatment of Parkinson's disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research