Beneficial effects of exogenous CDP-choline (citicoline) in EAE

Sir,I read with great interest the article by Skripuletz et al. (2015), who showed beneficial effects of exogenously applied CDP-choline (citicoline) in murine myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) and in cuprizone-induced mouse model of demyelination. I would like to congratulate the authors for their report, which already has been recognized as the best basic science paper published in the multiple sclerosis research area in 2014 (Hutchinson, 2015).In the discussion of their findings, Skripuletz et al. (2015) stated that, although several previous studies indicated that CDP-choline may have the capacity to protect cells such as neurons, …