The role of noradrenaline in cognition and cognitive disorders | Zendy

Negin Holland | Zendy; Trevor W. Robbins | Zendy; James B. Rowe | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The role of noradrenaline in cognition and cognitive disorders

Author(s) -

Negin Holland,

Trevor W. Robbins,

James B. Rowe

Publication year - 2021

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awab111

Subject(s) - cognition , neuroscience , psychology , cognitive psychology

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the forebrain originating from the locus coeruleus, acting through alpha and beta adrenoreceptors. Loss of these projections is common in neurodegenerative diseases and contributes to their cognitive and behavioural deficits. We review the evidence for a noradrenergic modulation of cognition in its contribution to Alzheimer's disease, Parkinson's disease and other cognitive disorders. We discuss the advances in human imaging and computational methods that quantify the locus coeruleus and its function in humans, and highlight the potential for new noradrenergic treatment strategies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research