CLIPreg: constructing translational regulatory networks from CLIP-, Ribo- and RNA-seq
Author(s) -
Baptiste Kerouanton,
Sebastian Schäfer,
Lena Ho,
Sonia Chothani,
Owen J. L. Rackham
Publication year - 2022
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btac363
Subject(s) - gene regulatory network , computational biology , regulation of gene expression , rna , construct (python library) , regulatory sequence , gene , biology , translational regulation , transcriptional regulation , computer science , bioinformatics , gene expression , genetics , messenger rna , translation (biology) , programming language
The creation and analysis of gene regulatory networks have been the focus of bioinformatics research and underpins much of what is known about gene regulation. However, as a result of a bias in the availability of data types that are collected, the vast majority of gene regulatory network resources and tools have focused on either transcriptional regulation or protein-protein interactions. This has left other areas of regulation, for instance, translational regulation, vastly underrepresented despite them having been shown to play a critical role in both health and disease.
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