deepSimDEF: deep neural embeddings of gene products and gene ontology terms for functional analysis of genes | Zendy

Ahmad Pesaranghader | Zendy; Stan Matwin | Zendy; Marina Sokolova | Zendy; JeanChristophe Grenier | Zendy; Robert G. Beiko | Zendy; Julie Hussin | Zendy

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deepSimDEF: deep neural embeddings of gene products and gene ontology terms for functional analysis of genes

Author(s) -

Ahmad Pesaranghader,

Stan Matwin,

Marina Sokolova,

JeanChristophe Grenier,

Robert G. Beiko,

Julie Hussin

Publication year - 2022

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btac304

Subject(s) - gene ontology , gene , computational biology , computer science , genetics , biology , artificial intelligence , gene expression

There is a plethora of measures to evaluate functional similarity (FS) of genes based on their co-expression, protein-protein interactions and sequence similarity. These measures are typically derived from hand-engineered and application-specific metrics to quantify the degree of shared information between two genes using their Gene Ontology (GO) annotations.

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