Open AccessFrom drug repositioning to target repositioning: prediction of therapeutic targets using genetically perturbed transcriptomic signatures
Author(s) -
Kensaku Maejima,
Makoto Iwata,
Yoshihiro Yamanishi
Publication year - 2022
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btac240
Subject(s) - drug repositioning , identification (biology) , computational biology , transcriptome , drug target , drug discovery , disease , drug development , drug , biology , gene , bioinformatics , medicine , genetics , pharmacology , gene expression , pathology , botany
A critical element of drug development is the identification of therapeutic targets for diseases. However, the depletion of therapeutic targets is a serious problem.