Open AccessGLYCO: a tool to quantify glycan shielding of glycosylated proteins
Author(s) -
Myungjin Lee,
Mateo Reveiz,
Reda Rawi,
Peter D. Kwong,
Gwo-Yu Chuang
Publication year - 2021
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btab791
Subject(s) - glycan , electromagnetic shielding , in silico , glycomics , glycosylation , computational biology , surface protein , computer science , chemistry , bioinformatics , biology , glycoprotein , materials science , biochemistry , gene , virology , composite material
Glycans play important roles in protein folding and cell-cell interactions-and, furthermore, glycosylation of protein antigens can dramatically impact immune responses. While there have been attempts to quantify the glycan shielding or coverage of a protein surface, none of the publicly available tools analyzes glycan shielding computationally at an atomistic level.