A gene-level methylome-wide association analysis identifies novel Alzheimer’s disease genes | Zendy

Chong Wu | Zendy; Jonathan R. Bradley | Zendy; Yanming Li | Zendy; Lang Wu | Zendy; HongWen Deng | Zendy

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A gene-level methylome-wide association analysis identifies novel Alzheimer’s disease genes

Author(s) -

Chong Wu,

Jonathan R. Bradley,

Yanming Li,

Lang Wu,

HongWen Deng

Publication year - 2021

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btab045

Subject(s) - epigenetics , dna methylation , biology , enhancer , genetics , gene , genetic association , transcriptome , computational biology , genome wide association study , disease , gene expression , genotype , single nucleotide polymorphism , medicine , pathology

Transcriptome-wide association studies (TWAS) have successfully facilitated the discovery of novel genetic risk loci for many complex traits, including late-onset Alzheimer's disease (AD). However, most existing TWAS methods rely only on gene expression and ignore epigenetic modification (i.e., DNA methylation) and functional regulatory information (i.e., enhancer-promoter interactions), both of which contribute significantly to the genetic basis of AD.

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