Open AccessA gene-level methylome-wide association analysis identifies novel Alzheimer’s disease genes
Author(s) -
Chong Wu,
Jonathan R. Bradley,
Yanming Liu,
Lang Wu,
HongWen Deng
Publication year - 2021
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btab045
Subject(s) - genome wide association study , epigenetics , dna methylation , genetic association , computational biology , biology , gene , genetics , enhancer , gene expression , single nucleotide polymorphism , genotype
Transcriptome-wide association studies (TWAS) have successfully facilitated the discovery of novel genetic risk loci for many complex traits, including late-onset Alzheimer's disease (AD). However, most existing TWAS methods rely only on gene expression and ignore epigenetic modification (i.e., DNA methylation) and functional regulatory information (i.e., enhancer-promoter interactions), both of which contribute significantly to the genetic basis of AD.