Open AccessIrregular Autonomic Modulation Predicts Risky Drinking and Altered Ventromedial Prefrontal Cortex Response to Stress in Alcohol Use Disorder
Author(s) -
Seung-Ju Hwang,
Jorge S. Martins,
Ryan J. Douglas,
Justin Choi,
Rajita Sinha,
Dongju Seo
Publication year - 2021
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agab064
Subject(s) - ventromedial prefrontal cortex , alcohol use disorder , functional magnetic resonance imaging , psychology , prefrontal cortex , amygdala , striatum , autonomic nervous system , anterior cingulate cortex , alcohol dependence , hippocampus , neuroscience , heart rate variability , medicine , audiology , heart rate , alcohol , blood pressure , cognition , dopamine , chemistry , biochemistry
Autonomic dysfunction has been associated with risky drinking and alcohol use disorder (AUD). Although autonomic nervous system (ANS) activity has been attributed to the ventromedial prefrontal cortex (VmPFC)-limbic-striatal regions, the specific role of ANS disruption in AUD and its association with these regions remain unclear. Using functional magnetic resonance imaging (fMRI) and concurrent electrocardiogram (ECG), the current study examined neural correlates of ANS activity in AUD and its role in AUD pathology.