Irregular Autonomic Modulation Predicts Risky Drinking and Altered Ventromedial Prefrontal Cortex Response to Stress in Alcohol Use Disorder | Zendy

SeungJu Hwang | Zendy; Jorge S. Martins | Zendy; Ryan J. Douglas | Zendy; Justin Choi | Zendy; Rajita Sinha | Zendy; Dongju Seo | Zendy

Open Access

Irregular Autonomic Modulation Predicts Risky Drinking and Altered Ventromedial Prefrontal Cortex Response to Stress in Alcohol Use Disorder

Author(s) -

SeungJu Hwang,

Jorge S. Martins,

Ryan J. Douglas,

Justin Choi,

Rajita Sinha,

Dongju Seo

Publication year - 2021

Publication title -

alcohol and alcoholism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 99

eISSN - 1464-3502

pISSN - 0735-0414

DOI - 10.1093/alcalc/agab064

Subject(s) - ventromedial prefrontal cortex , prefrontal cortex , alcohol use disorder , alcohol , psychology , neuroscience , fight or flight response , medicine , cognition , biology , biochemistry , gene

Autonomic dysfunction has been associated with risky drinking and alcohol use disorder (AUD). Although autonomic nervous system (ANS) activity has been attributed to the ventromedial prefrontal cortex (VmPFC)-limbic-striatal regions, the specific role of ANS disruption in AUD and its association with these regions remain unclear. Using functional magnetic resonance imaging (fMRI) and concurrent electrocardiogram (ECG), the current study examined neural correlates of ANS activity in AUD and its role in AUD pathology.

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