Open AccessImpact of a pharmacist-led, mHealth-based intervention on tacrolimus trough variability in kidney transplant recipients: A report from the TRANSAFE Rx randomized controlled trial
Author(s) -
James N. Fleming,
Mulugeta Gebregziabher,
Aurora Posadas,
Zemin Su,
John W. McGillicuddy,
David J. Taber
Publication year - 2021
Publication title -
american journal of health-system pharmacy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.487
H-Index - 96
eISSN - 1535-2900
pISSN - 1079-2082
DOI - 10.1093/ajhp/zxab157
Subject(s) - tacrolimus , medicine , mhealth , randomized controlled trial , pharmacist , psychological intervention , kidney transplant , kidney transplantation , emergency medicine , transplantation , pharmacy , family medicine , nursing
Nonadherence is a leading cause of death-censored allograft loss in kidney transplant recipients. Strong associations have tied tacrolimus intrapatient variability (IPV) to degree of nonadherence and high tacrolimus IPV to clinical endpoints such as rejection and allograft loss. Nonadherence is a dynamic, complex problem best targeted by multidimensional interventions, including mobile health (mHealth) technologies.