Open AccessSeventy Years of Tuberculosis Prevention: Efficacy, Effectiveness, Toxicity, Durability, and Duration
Author(s) -
Nicole Salazar-Austin,
David W. Dowdy,
Richard E. Chaisson,
Jonathan E. Golub
Publication year - 2019
Publication title -
american journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.33
H-Index - 256
eISSN - 1476-6256
pISSN - 0002-9262
DOI - 10.1093/aje/kwz172
Subject(s) - medicine , tuberculosis , chemoprophylaxis , public health , epidemiology , disease , environmental health , cause of death , intensive care medicine , surgery , pathology
Tuberculosis (TB) has been a leading infectious cause of death worldwide for much of human history, with 1.6 million deaths estimated in 2017. The Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health has played an important role in understanding and responding to TB, and it has made particularly substantial contributions to prevention of TB with chemoprophylaxis. TB preventive therapy is highly efficacious in the prevention of TB disease, yet it remains underutilized by TB programs worldwide despite strong evidence to support its use in high-risk groups, such as people living with HIV and household contacts, including those under 5 years of age. We review the evidence for TB preventive therapy and discuss the future of TB prevention.