Open AccessKeratin 17 Is a Novel Cytologic Biomarker for Urothelial Carcinoma Diagnosis
Author(s) -
Sruthi Babu,
Nam W. Kim,
Maoxin Wu,
Ina Chan,
Luisa F. EscobarHoyos,
Kenneth R. Shroyer
Publication year - 2021
Publication title -
american journal of clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.859
H-Index - 128
eISSN - 1943-7722
pISSN - 0002-9173
DOI - 10.1093/ajcp/aqab050
Subject(s) - medicine , cytology , urothelial carcinoma , biopsy , biomarker , urine , cohort , urine cytology , pathology , carcinoma , gastroenterology , urology , bladder cancer , cancer , biology , biochemistry
The microscopic features of urine cytology specimens are subjective and may not reliably distinguish between benign urothelial cells and low-grade urothelial carcinoma (UC). Prior studies demonstrated that keratin 17 (K17) detection in biopsies is highly sensitive for UC. The current study aimed to define K17 diagnostic test performance for initial screening and detect recurrent UC in urine specimens.