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Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study
Author(s) -
Konstantinos K. Tsilidis,
Nikos Papadimitriou,
Niki Dimou,
Dipender Gill,
Sarah J. Lewis,
Richard M. Martin,
Neil Murphy,
Georgios Markozannes,
Verena Zuber,
Amanda J. Cross,
Kimberley Burrows,
David S. López,
Timothy J. Key,
Ruth C. Travis,
Aurora PerezCornago,
David J. Hunter,
Fränzel JB van Duijnhoven,
Demetrius Albanes,
Volker Arndt,
Sonja I. Berndt,
Stéphane Bézieau,
D. Timothy Bishop,
Juergen Boehm,
Hermann Brenner,
Andrea N. BurnettHartman,
Peter T. Campbell,
Graham Casey,
Sergi Castellví–Bel,
Andrew T. Chan,
Jenny Chang-Claude,
Albert de la Chapelle,
Jane C. Figueiredo,
Steven Gallinger,
Graham G. Giles,
Phyllis J. Goodman,
Andrea Gsur,
Jochen Hampe,
Heather Hampel,
Michael Hoffmeister,
Mark A. Jenkins,
Temitope O. Keku,
SunSeog Kweon,
Susanna C. Larsson,
Loı̈c Le Marchand,
Christopher I. Li,
Li Li,
Annika Lindblom,
Vicente Martín,
Roger L. Milne,
Vı́ctor Moreno,
Hongmei Nan,
Rami Nassir,
Polly A. Newcomb,
Kenneth Offit,
Paul D.P. Pharoah,
Elizabeth A. Platz,
John D. Potter,
Lihong Qi,
Gad Rennert,
Lori C. Sakoda,
Clemens Schafmayer,
Martha L. Slattery,
Linda Snetselaar,
Jeanette Schenk,
Stephen N. Thibodeau,
Cornelia M. Ulrich,
Bethany Van Guelpen,
Sophia Harlid,
Kala Visvanathan,
Ludmila Vodičková,
Hansong Wang,
Emily White,
Alicja Wolk,
Michael O. Woods,
Anna H. Wu,
Wei Zheng,
Bas Bueno-de-Mesquita,
MarieChristine BoutronRuault,
David J. Hughes,
Paula Jakszyn,
Tilman Kühn,
Domenico Palli,
Elio Ríboli,
Edward L. Giovannucci,
Barbara L. Banbury,
Stephen B. Gruber,
Ulrike Peters,
Marc J. Gunter
Publication year - 2021
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/nqab003
Subject(s) - mendelian randomization , colorectal cancer , medicine , micronutrient , cancer , randomized controlled trial , oncology , breast cancer , relative risk , vitamin d and neurology , gastroenterology , physiology , confidence interval , biology , genetics , pathology , genotype , genetic variants , gene
The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.

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