Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver | Zendy

David A. Horita | Zendy; SunIl Hwang | Zendy; Julie M. Stegall | Zendy; Walter B. Friday | Zendy; David Kirchner | Zendy; Steven H. Zeisel | Zendy

Open Access

Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver

Author(s) -

David A. Horita,

SunIl Hwang,

Julie M. Stegall,

Walter B. Friday,

David Kirchner,

Steven H. Zeisel

Publication year - 2020

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.1093/ajcn/nqaa439

Subject(s) - choline , betaine , phosphatidylcholine , chemistry , crossover study , endocrinology , medicine , population , phosphocholine , in vivo magnetic resonance spectroscopy , biochemistry , pathology , phospholipid , magnetic resonance imaging , placebo , alternative medicine , environmental health , membrane , radiology

Choline deficiency has numerous negative health consequences; although the preponderance of the US population consumes less than the recommended Adequate Intake (AI), clinical assessment of choline status is difficult. Further, several pathways involved in primary metabolism of choline are estrogen-sensitive and the AI for premenopausal women is lower than that for men.

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