Impact of high-dose folic acid supplementation in pregnancy on biomarkers of folate status and 1-carbon metabolism: An ancillary study of the Folic Acid Clinical Trial (FACT) | Zendy

Malia S. Q. Murphy | Zendy; Katherine A. Muldoon | Zendy; Hauna Sheyholislami | Zendy; Nathalie A. Behan | Zendy; Yvonne Lamers | Zendy; Natalie Rybak | Zendy; Ruth Rennicks White | Zendy; Alysha L. J. DingwallHarvey | Zendy; Laura Gaudet | Zendy; Graeme N. Smith | Zendy; Mark Walker | Zendy; Shi Wu Wen | Zendy; Amanda J. MacFarlane | Zendy

Open Access

Impact of high-dose folic acid supplementation in pregnancy on biomarkers of folate status and 1-carbon metabolism: An ancillary study of the Folic Acid Clinical Trial (FACT)

Author(s) -

Malia S. Q. Murphy,

Katherine A. Muldoon,

Hauna Sheyholislami,

Nathalie A. Behan,

Yvonne Lamers,

Natalie Rybak,

Ruth Rennicks White,

Alysha L. J. DingwallHarvey,

Laura Gaudet,

Graeme N. Smith,

Mark Walker,

Shi Wu Wen,

Amanda J. MacFarlane

Publication year - 2020

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.1093/ajcn/nqaa407

Subject(s) - medicine , placebo , homocysteine , pregnancy , gastroenterology , physiology , endocrinology , biology , alternative medicine , pathology , genetics

Periconceptional folic acid (FA) supplementation is recommended to prevent the occurrence of neural tube defects. Currently, most over-the-counter FA supplements in Canada and the United States contain 1 mg FA and some women are prescribed 5 mg FA/d. High-dose FA is hypothesized to impair 1-carbon metabolism. We aimed to determine folate and 1-carbon metabolism biomarkers in pregnant women exposed to 1 mg or 5 mg FA.

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