Optimization of therapeutic antibodies | Zendy

Bo Wang | Zendy; Sachith Gallolu Kankanamalage | Zendy; Jianbo Dong | Zendy; Yue Liu | Zendy

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Optimization of therapeutic antibodies

Author(s) -

Bo Wang,

Sachith Gallolu Kankanamalage,

Jianbo Dong,

Yue Liu

Publication year - 2021

Publication title -

antibody therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.579

H-Index - 5

ISSN - 2516-4236

DOI - 10.1093/abt/tbab003

Subject(s) - immunogenicity , antibody , pharmacodynamics , pharmacokinetics , computational biology , protein engineering , antigen , pharmacology , medicine , chemistry , immunology , biology , biochemistry , enzyme

In this review, we have summarized the current landscape of therapeutic antibody optimization for successful development. By engineering antibodies with display technology, computer-aided design and site mutagenesis, various properties of the therapeutic antibody candidates can be improved with the purpose of enhancing their safety, efficacy and developability. These properties include antigen binding affinity and specificity, biological efficacy, pharmacokinetics and pharmacodynamics, immunogenicity and physicochemical developability features. A best-in-class strategy may require the optimization of all these properties to generate a good therapeutic antibody.

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