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Two major components of nuclear Cajal bodies (CBs) are small CB-specific scaRNPs and their targets, spliceosomal snRNPs. The intrinsically disordered phosphoprotein Nopp140 is required to recruit and retain all scaRNPs including telomerase in CBs. Knockdown of Nopp140 releases all scaRNPs, but not snRNPs, causing gradual telomere lengthening.

Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length