Open AccessNopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length
Author(s) -
Jonathan Bizarro,
Anurag Bhardwaj,
Susan Smith,
U. Thomas Meier
Publication year - 2019
Publication title -
molecular biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.463
H-Index - 225
eISSN - 1939-4586
pISSN - 1059-1524
DOI - 10.1091/mbc.e19-08-0429
Subject(s) - biology , cajal body , telomere , telomerase , microbiology and biotechnology , telomerase rna component , genetics , dna , telomerase reverse transcriptase , gene , rna , rna splicing
Two major components of nuclear Cajal bodies (CBs) are small CB-specific scaRNPs and their targets, spliceosomal snRNPs. The intrinsically disordered phosphoprotein Nopp140 is required to recruit and retain all scaRNPs including telomerase in CBs. Knockdown of Nopp140 releases all scaRNPs, but not snRNPs, causing gradual telomere lengthening.