Open AccessMechanisms of invasion and motility of high-grade gliomas in the brain
Author(s) -
Devin B. Mair,
Heather Ames,
Rong Li
Publication year - 2018
Publication title -
molecular biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.463
H-Index - 225
eISSN - 1939-4586
pISSN - 1059-1524
DOI - 10.1091/mbc.e18-02-0123
Subject(s) - motility , biology , cell migration , glioma , integrin , extracellular matrix , microbiology and biotechnology , cell , cytoskeleton , cell polarity , extracellular , actin cytoskeleton , cd44 , transmembrane protein , receptor , cancer research , biochemistry
High-grade gliomas are especially difficult tumors to treat due to their invasive behavior. This has led to extensive research focusing on arresting glioma cell migration. Cell migration involves the sensing of a migratory cue, followed by polarization in the direction of the cue, and reorganization of the actin cytoskeleton to allow for a protrusive leading edge and a contractile trailing edge. Transmission of these forces to produce motility also requires adhesive interactions of the cell with the extracellular microenvironment. In glioma cells, transmembrane receptors such as CD44 and integrins bind the cell to the surrounding extracellular matrix that provides a substrate on which the cell can exert the requisite forces for cell motility. These various essential parts of the migratory machinery are potential targets to halt glioma cell invasion. In this review, we discuss the mechanisms of glioma cell migration and how they may be targeted in anti-invasion therapies.