Open AccessDribble, theDrosophilaKRR1p Homologue, Is Involved in rRNA Processing
Author(s) -
Ho Yin Edwin Chan,
Saverio Brogna,
Cahir J. O’Kane
Publication year - 2001
Publication title -
molecular biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.463
H-Index - 225
eISSN - 1939-4586
pISSN - 1059-1524
DOI - 10.1091/mbc.12.5.1409
Subject(s) - biology , nucleolus , mutant , ribosomal rna , gene , homologous chromosome , drosophila (subgenus) , genetics , microbiology and biotechnology , embryo , yeast , nucleus
The Drosophila dribble (dbe) gene encodes a KH domain protein, homologous to yeast KRR1p. Expression of dbe transcripts is ubiquitous during embryogenesis. Overexpressed Dribble protein is localized in the nucleus and in some cell types in a subregion of the nucleolus. Homozygous dbe mutants die at first instar larval stage. Clonal analyses suggest that dbe(+) is required for survival of dividing cells. In dbe mutants, a novel rRNA-processing defect is found and accumulation of an abnormal rRNA precursor is detected.