Open AccessCryo-Electron Microscopy Structures of the Pneumoviridae Polymerases
Author(s) -
Dong Cao,
Bo Liang
Publication year - 2021
Publication title -
viral immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.777
H-Index - 61
eISSN - 1557-8976
pISSN - 0882-8245
DOI - 10.1089/vim.2020.0018
Subject(s) - cryo electron microscopy , human metapneumovirus , polymerase , rna , electron microscope , biology , microscopy , virology , virus , chemistry , biophysics , genetics , physics , gene , respiratory system , anatomy , respiratory tract infections , optics
The resolution revolution of cryo-electron microscopy (cryo-EM) has made a significant impact on the structural analysis of the Pneumoviridae multifunctional RNA polymerases. In recent months, several high-resolution structures of apo RNA polymerases of Pneumoviridae , which includes the human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV), have been determined by single-particle cryo-EM. These structures illustrated high similarities and minor differences between the Pneumoviridae polymerases and revealed the potential mechanisms of the Pneumoviridae RNA synthesis.