Open AccessCross-Reactive Memory CD4+T Cells Alter the CD8+T-Cell Response to Heterologous Secondary Dengue Virus Infections in Mice in a Sequence-Specific Manner
Author(s) -
Coreen M. Beaumier,
Alan L. Rothman
Publication year - 2009
Publication title -
viral immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.777
H-Index - 61
eISSN - 1557-8976
pISSN - 0882-8245
DOI - 10.1089/vim.2008.0089
Subject(s) - dengue virus , biology , virology , serotype , cd8 , cytotoxic t cell , t cell , dengue fever , adoptive cell transfer , immunology , heterologous , immune system , genetics , in vitro , gene
Secondary dengue virus (DENV) infection is a major factor contributing to the risk for severe disease, an effect that depends upon the sequence of infection with different DENV serotypes. We previously reported sequence-dependent effects of secondary DENV infection on CD8+ T-cell responses in mice. To further evaluate the effect of infection sequence, we analyzed DENV-specific CD4+ T-cell responses and their relationship to the CD8+ T-cell response. Serotype cross-reactivity of CD4+ T-cell responses also depended upon the sequence of serotypes in this model. Furthermore, adoptive transfer of memory CD4+ T cells altered the response of memory CD8+ T cells to secondary infection. These data demonstrate the interaction of different components of the T-cell response in determining the immunological outcome of secondary DENV infection.