Open AccessRegenerative Scar-Free Skin Wound Healing
Author(s) -
Mehri Monavarian,
Safaa Kader,
Seyedsina Moeinzadeh,
Esmaiel Jabbari
Publication year - 2019
Publication title -
tissue engineering. part b, reviews/tissue engineering. part b, reviews.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.579
H-Index - 91
eISSN - 1937-3376
pISSN - 1937-3368
DOI - 10.1089/ten.teb.2018.0350
Subject(s) - wound healing , scars , regeneration (biology) , regenerative medicine , medicine , scar tissue , extracellular matrix , tissue engineering , surgery , skin repair , biomedical engineering , stem cell , biology , microbiology and biotechnology
Millions of people every year develop scars in response to skin injuries after surgery, trauma, or burns with significant undesired physical and psychological effects. This review provides an update on engineering strategies for scar-free wound healing and discusses the role of different cell types, growth factors, cytokines, and extracellular components in regenerative wound healing. The use of pro-regenerative matrices combined with engineered cells with less intrinsic potential for fibrogenesis is a promising strategy for achieving scar-free skin tissue regeneration.