A Method for High-Throughput Robotic Assembly of Three-Dimensional Vascular Tissue | Zendy

Christopher J. Nycz | Zendy; Hannah A. Strobel | Zendy; Kathy Suqui | Zendy; Jonian Grosha | Zendy; Gregory S. Fischer | Zendy; Marsha W. Rolle | Zendy

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A Method for High-Throughput Robotic Assembly of Three-Dimensional Vascular Tissue

Author(s) -

Christopher J. Nycz,

Hannah A. Strobel,

Kathy Suqui,

Jonian Grosha,

Gregory S. Fischer,

Marsha W. Rolle

Publication year - 2019

Publication title -

tissue engineering part a

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.964

H-Index - 111

eISSN - 1937-335X

pISSN - 1937-3341

DOI - 10.1089/ten.tea.2018.0288

Subject(s) - computer science , biomedical engineering , stacking , throughput , tissue engineering , fuse (electrical) , nanotechnology , materials science , chemistry , engineering , telecommunications , electrical engineering , organic chemistry , wireless

Self-assembled tissues have potential to serve both as implantable grafts and as tools for disease modeling and drug screening. For these applications, tissue production must ultimately be scaled-up and automated. Limited technologies exist for precisely manipulating self-assembled tissues, which are fragile early in culture. Here, we presented a method for automatically stacking self-assembled smooth muscle cell rings onto mandrels, using a custom-designed well plate and robotic punch system. Rings then fuse into tissue-engineered blood vessels (TEBVs). This is a critical step toward automating TEBV production that may be applied to other tubular tissues as well.

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