Open AccessDevelopment of Intestinal Scaffolds that Mimic Native Mammalian Intestinal Tissue
Author(s) -
Mitchell R. Ladd,
Cait M. Costello,
Carolyn Gosztyla,
Adam D. Werts,
Blake Johnson,
William B. Fulton,
Laura Y. Martin,
Elizabeth J. Redfield,
Bryan D. Crawford,
Rohan Panaparambil,
Chhinder P. Sodhi,
John C. March,
David J. Hackam
Publication year - 2019
Publication title -
tissue engineering. part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 111
eISSN - 1937-335X
pISSN - 1937-3341
DOI - 10.1089/ten.tea.2018.0239
Subject(s) - scaffold , drug delivery , tissue engineering , small intestine , biomedical engineering , nanotechnology , chemistry , microbiology and biotechnology , materials science , biology , biochemistry , engineering
This study is significant because it demonstrates an attempt to design a scaffold specifically for small intestine using a novel fabrication method, resulting in an architecture that resembles intestinal villi. In addition, we use the versatile polymer poly(glycerol sebacate) (PGS) for artificial intestine, which has tunable mechanical and degradation properties that can be harnessed for further fine-tuning of scaffold design. Moreover, the utilization of PGS allows for future development of growth factor and drug delivery from the scaffolds to promote artificial intestine formation.