Open AccessDevelopment of Decellularized Human Umbilical Arteries as Small-Diameter Vascular Grafts
Author(s) -
Liqiong Gui,
Akihito Muto,
Stephen A. Chan,
Christopher K. Breuer,
Laura E. Niklason
Publication year - 2009
Publication title -
tissue engineering. part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 111
eISSN - 1937-335X
pISSN - 1937-3341
DOI - 10.1089/ten.tea.2008.0526
Subject(s) - decellularization , biomedical engineering , medicine , anatomy , tissue engineering
Developing a tissue-engineered small-diameter (<6mm) vascular graft for reconstructive surgery has remained a challenge for the past several decades. This study was conducted to develop a decellularized umbilical artery and to evaluate its composition, endothelial cell compatibility, mechanical properties, and in vivo stability for potential use as a small-diameter vascular graft.