Open AccessCreation of New Bone by the Percutaneous Injection of Human Bone Marrow Stromal Cell and HA/TCP Suspensions
Author(s) -
Mahesh H. Mankani,
Sergei A. Kuznetsov,
Grayson W. Marshall,
Pamela Gehron Robey
Publication year - 2008
Publication title -
tissue engineering. part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 111
eISSN - 1937-335X
pISSN - 1937-3341
DOI - 10.1089/ten.tea.2007.0348
Subject(s) - stromal cell , bone marrow , human bone , biomedical engineering , percutaneous , chemistry , cell , pathology , medicine , surgery , biochemistry , in vitro
The in vivo transplantation assay has become a valuable tool for assessing the osteogenic potential of diverse cell populations. It has required that cells are cotransplanted with a matrix into recipient animals using large incisions and extensive dissections. Here, we demonstrate that transplants of an osteogenic cell population, bone marrow stromal cells (BMSCs), are capable of assembling into mature bone organs when injected as suspensions of cells and a particulate matrix.