Open AccessA Serum Level of Squamous Cell Carcinoma Antigen as a Real-Time Biomarker of Atopic Dermatitis
Author(s) -
Masaki Shimomura,
Yuji Okura,
Yutaka Takahashi,
Ichiro Kobayashi
Publication year - 2021
Publication title -
pediatric allergy, immunology, and pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 22
eISSN - 2151-3228
pISSN - 2151-321X
DOI - 10.1089/ped.2021.0049
Subject(s) - interquartile range , medicine , atopic dermatitis , biomarker , scorad , gastroenterology , immunology , disease , dermatology life quality index , biochemistry , chemistry
Background: Although serum levels of squamous cell carcinoma antigen (SCCA) are elevated in atopic dermatitis (AD), their clinical utility has not been fully elucidated. Methods: Thirty-three cases of AD who admitted to our hospital were analyzed. Results: Baseline characteristics on admission were as follows: median age 19 months [interquartile range (IQR), 12-52 months], median objective severity scoring of atopic dermatitis (O-SCORAD) 19.2 (IQR, 4.2-36.0), and median serum SCCA levels 3.2 ng/mL (IQR, 2.1-6.8 ng/mL). O-SCORAD significantly correlated with serum SCCA levels (rs = 0.865, P < 0.001). In 9 cases whose information before and after treatment was available (median interval, 3 days; IQR 2-5 days), median serum SCCA levels significantly decreased from 8.0 to 2.0 ng/mL ( P = 0.008) after the treatment. Conclusions: Serum levels of total SCCA rapidly declined in response to the treatment and could be used as a real-time biomarker in childhood AD.