Open AccessNo Evidence of a Difference in Susceptibility-Weighted Imaging Lesion Burden or Functional Network Connectivity between Children with Typical and Delayed Recovery Two Weeks Post-Concussion
Author(s) -
Jesse Shapiro,
Michael Takagi,
Tim Silk,
Nicholas Anderson,
Cathriona Clarke,
Gavin A Davis,
Stephen Hearps,
Vera Ignjatović,
Vanessa C Rausa,
Marc L. Seal,
Franz E Babl,
Vicki Anderson
Publication year - 2021
Publication title -
journal of neurotrauma
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.653
H-Index - 149
eISSN - 1557-9042
pISSN - 0897-7151
DOI - 10.1089/neu.2021.0069
Subject(s) - concussion , neuroimaging , susceptibility weighted imaging , medicine , traumatic brain injury , functional neuroimaging , lesion , functional imaging , post concussion syndrome , magnetic resonance imaging , resting state fmri , physical medicine and rehabilitation , poison control , injury prevention , surgery , radiology , psychiatry , emergency medicine
Susceptibility weighted imaging (SWI) and resting state functional magnetic resonance imaging have been highlighted as two novel neuroimaging modalities that have been underutilized when attempting to predict whether a child with concussion will recover normally or have a delayed recovery course. This study aimed to investigate whether there was a difference between children who recover normally from a concussion and children with delayed recovery in terms of SWI lesion burden and resting state network makeup. Forty-one children who presented to the emergency department of a tertiary level pediatric hospital with concussion participated in this study as a part of a larger prospective, longitudinal observational cohort study into concussion assessment and recovery. Children underwent neuroimaging 2 weeks post-injury and were classified as either normally recovering ( n = 27), or delayed recovering ( n = 14) based on their post-concussion symptoms at 2 weeks post-injury. No participants showed lesions detected using SWI; therefore, no group differences could be assessed. No between-group resting state network differences were uncovered using dual regression analysis. These findings, alongside previously published work, suggest that potential causes of delayed recovery from concussion may not be found using current neuroimaging paradigms.