Open AccessDiffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury: A CENTER-TBI Validation Study
Author(s) -
Frederick A. Zeiler,
François Mathieu,
Miguel Monteiro,
Ben Glocker,
Ari Ercole,
Erta Beqiri,
Manuel Cabeleira,
Nino Stocchetti,
Peter Smielewski,
Marek Czosnyka,
Virginia Newcombe,
David Me,
Audny Anke,
BoMichael Bellander,
András Büki,
Marco Carbonara,
Arturo Chieregato,
Giuseppe Citerio,
Hans Clusmann,
Endre Czeiter,
Bart Depreitere,
Shirin Frisvold,
Raimund Helbok,
Stefan Jankowski,
Danile Kondziella,
LarsOwe D. Koskinen,
Ana Kowark,
Geert Meyfroidt,
Kirsten Moeller,
David Nelson,
Anna Piippo-Karjalainen,
Andreea Rădoi,
Arminas Ragauskas,
Rahul Raj,
Jonathan R. Rhodes,
Saulius Ročka,
Rolf Rossaint,
Juan Sahuquillo,
Oliver Sakowitz,
Nina Sundström,
Riikka Takala,
Tomas Tamošuitis,
Olli Tenovuo,
Peter Vajkoczy,
Alessia Vargiolu,
Rimantas Vilcinis,
Stefan Wolf,
Alexander Younsi
Publication year - 2020
Publication title -
journal of neurotrauma
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.653
H-Index - 149
eISSN - 1557-9042
pISSN - 0897-7151
DOI - 10.1089/neu.2019.6959
Subject(s) - medicine , traumatic brain injury , trauma center , midline shift , intracranial pressure , diffuse axonal injury , glasgow coma scale , intensive care unit , prospective cohort study , univariate analysis , anesthesia , cardiology , retrospective cohort study , radiology , computed tomography , multivariate analysis , psychiatry
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further explore these associations using the prospective multi-center Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) high-resolution intensive care unit (HR ICU) data set. Using the CENTER-TBI HR ICU sub-study cohort, we evaluated those patients with both archived high-frequency digital physiology (100 Hz or higher) and the presence of a digital admission CT scan. Physiological signals were processed for pressure reactivity index (PRx) and both the percent (%) time above defined PRx thresholds and mean hourly dose above threshold. Admission CT injury scores were obtained from the database. Quantitative contusion, edema, intraventricular hemorrhage (IVH), and extra-axial lesion volumes were obtained via semi-automated segmentation. Comparison between admission CT characteristics and PRx metrics was conducted using Mann-U, Jonckheere-Terpstra testing, with a combination of univariate linear and logistic regression techniques. A total of 165 patients were included. Cisternal compression and high admission Rotterdam and Helsinki CT scores, and Marshall CT diffuse injury sub-scores were associated with increased percent (%) time and hourly dose above PRx threshold of 0, +0.25, and +0.35 ( p < 0.02 for all). Logistic regression analysis displayed an association between deep peri-contusional edema and mean PRx above a threshold of +0.25. These results suggest that diffuse injury patterns, consistent with acceleration/deceleration forces, are associated with impaired cerebrovascular reactivity. Diffuse admission intracranial injury patterns appear to be consistently associated with impaired cerebrovascular reactivity, as measured through PRx. This is in keeping with the previous single-center retrospective literature on the topic. This study provides multi-center validation for those results, and provides preliminary data to support potential risk stratification for impaired cerebrovascular reactivity based on injury pattern.