Open AccessCerium Oxide Nanoparticles Improve Outcome afterIn VitroandIn VivoMild Traumatic Brain Injury
Author(s) -
Zachary S. Bailey,
Eric Nilson,
John A. Bates,
Adewole Oyalowo,
Kevin S. Hockey,
Venkata Siva Sai Sujith Sajja,
Chevon N. Thorpe,
H. Gary Rogers,
Bryce Dunn,
Aaron S Frey,
Marc Billings,
Christopher A Sholar,
Amy L. Hermundstad,
C.V. Sreeranjit Kumar,
Pamela J. VandeVord,
Beverly A. Rzigalinski
Publication year - 2020
Publication title -
journal of neurotrauma
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.653
H-Index - 149
eISSN - 1557-9042
pISSN - 0897-7151
DOI - 10.1089/neu.2016.4644
Subject(s) - traumatic brain injury , oxidative stress , in vivo , antioxidant , cerium oxide , pharmacology , free radical theory of aging , medicine , neuroprotection , in vitro , chemistry , biochemistry , biology , microbiology and biotechnology , psychiatry , catalysis
Mild traumatic brain injury results in aberrant free radical generation, which is associated with oxidative stress, secondary injury signaling cascades, mitochondrial dysfunction, and poor functional outcome. Pharmacological targeting of free radicals with antioxidants has been examined as an approach to treatment, but has met with limited success in clinical trials. Conventional antioxidants that are currently available scavenge a single free radical before they are destroyed in the process. Here, we report for the first time that a novel regenerative cerium oxide nanoparticle antioxidant reduces neuronal death and calcium dysregulation after in vitro trauma. Further, using an in vivo model of mild lateral fluid percussion brain injury in the rat, we report that cerium oxide nanoparticles also preserve endogenous antioxidant systems, decrease macromolecular free radical damage, and improve cognitive function. Taken together, our results demonstrate that cerium oxide nanoparticles are a novel nanopharmaceutical with potential for mitigating neuropathological effects of mild traumatic brain injury and modifying the course of recovery.