Open Access2′-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity
Author(s) -
Dmytro Honcharenko,
Cristina S. J. Rocha,
Karin E. Lundin,
Jyotirmoy Maity,
Stefan Milton,
Ulf Tedebark,
Merita Murtola,
Małgorzata Honcharenko,
Andis Slaitas,
C. I. Edvard Smith,
Rula Zain,
Roger Strömberg
Publication year - 2022
Publication title -
nucleic acid therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.255
H-Index - 67
eISSN - 2159-3345
pISSN - 2159-3337
DOI - 10.1089/nat.2021.0086
Subject(s) - oligonucleotide , splice , chemistry , phosphodiester bond , stereochemistry , endosome , biochemistry , rna , dna , intracellular , gene