Open Access2′-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity
Author(s) -
Dmytro Honcharenko,
Cristina S. J. Rocha,
Karin E. Lundin,
Jyotirmoy Maity,
Stefan Milton,
Ulf Tedebark,
Merita Murtola,
Małgorzata Honcharenko,
Andis Slaitas,
Smith Rjh,
Rula Zain,
Roger Strömberg
Publication year - 2022
Publication title -
nucleic acid therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.255
H-Index - 67
eISSN - 2159-3345
pISSN - 2159-3337
DOI - 10.1089/nat.2021.0086
Subject(s) - oligonucleotide , splice , chemistry , phosphodiester bond , stereochemistry , endosome , biochemistry , rna , dna , intracellular , gene
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