Open AccessLow Prenatal Vitamin D Metabolite Ratio and Subsequent Postpartum Depression Risk
Author(s) -
Eynav Elgavish Accortt,
Chander Arora,
James Mirocha,
Susan Jackman,
Richard Liang,
S. Ananth Karumanchi,
Anders H. Berg,
Calvin J. Hobel
Publication year - 2021
Publication title -
journal of women's health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.195
H-Index - 98
eISSN - 1931-843X
pISSN - 1540-9996
DOI - 10.1089/jwh.2019.8209
Subject(s) - medicine , vitamin d and neurology , pregnancy , biomarker , depression (economics) , metabolite , vitamin d deficiency , logistic regression , obstetrics , risk factor , postpartum depression , biology , genetics , macroeconomics , economics , biochemistry
Background: Depression is a common complication of pregnancy and vitamin D deficiency is one biological risk factor for postpartum depression (PPD). Materials and Methods: We evaluated the ratio of 24,25(OH) 2 D and 25(OH)D serum concentrations referred to as the Vitamin D Metabolite Ratio (VMR), a new candidate biomarker during pregnancyand its relationship with PPD. Women were enrolled in the first trimester of pregnancy and followed through four timepoints. Results: A total of 89 women had complete depression, biomarker and demographic data and 34% were at risk for PPD (CES-D≥16). Stepwise multiple logistic regression models for PPD risk were carried out with eight predictors. Results showed that only lower VMR, OR = 1.43, 95% CI 1.10-1.86, p = 0.007, and Hispanic/Latina identification, OR = 3.83, 95% CI 1.44-10.92, p = 0.007 were significantly associated with higher PPD risk. Conclusion: Routine prenatal screening for vitamin D metabolites, particularly in Hispanic/Latina women, may identify women at risk for PPD.