Open AccessNutraceutical Eriocitrin (Eriomin) Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation: A Crossover-Randomized Clinical Trial
Author(s) -
Thaís Borges César,
Fernanda Maria Manzini Ramos,
Camila M. Ribeiro
Publication year - 2022
Publication title -
journal of medicinal food
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 80
eISSN - 1557-7600
pISSN - 1096-620X
DOI - 10.1089/jmf.2021.0181
Subject(s) - medicine , crossover study , glycemic , placebo , insulin resistance , diabetes mellitus , endocrinology , glucose homeostasis , glucagon , insulin , systemic inflammation , blood pressure , adiponectin , randomized controlled trial , inflammation , gastroenterology , alternative medicine , pathology
This double-blind, randomized, placebo/controlled, crossover study evaluated the efficacy of Eriomin ® in reducing hyperglycemia and improving diabetes-related biomarkers in individuals with hyperglycemia above 110 mg/dL (mean 123 ± 18 mg/dL). Subjects ( n = 30), divided into two groups (Eriomin or Placebo), who received a dose of 200 mg/d of the designated supplement for 12 weeks and, after a washout period of 2 weeks, switched to the other supplement in the following 12 weeks. Assessments of biochemical, metabolic, inflammatory, blood pressure, anthropometry, and dietary parameters were performed at the beginning and end of each intervention. Treatment with 200 mg/d of Eriomin significantly decreased blood glucose (-5%), homeostasis model assessment of insulin resistance (-11%), glucagon (-13%), interleukin-6 (-14%), tumor necrosis factor alpha (-20%), and alkaline phosphatase (-13%); but increased glucagon-like peptide 1 (GLP-1) by (17%) ( P ≤ .05). At the end of the placebo period, there was a 13% increase in triglycerides ( P ≤ .05). Other parameters evaluated did not change with Eriomin or placebo. In conclusion, intervention with Eriomin benefited the glycemic control of prediabetic and diabetic patients, with higher blood glucose levels, by increasing GLP-1 and decreasing systemic inflammation.