Open AccessThe Effect of Continuous Versus Pericycle Antiretroviral Therapy on IL-2 Responsiveness
Author(s) -
Letha M. Healey,
Barbara Hahn,
Catherine Rehm,
Joseph W. Adelsberger,
Jing Qin,
Dean Follmann,
Jorge A. Tavel,
Joseph A. Kovacs,
Irini Sereti,
Richard T. Davey
Publication year - 2008
Publication title -
journal of interferon and cytokine research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 94
eISSN - 1557-7465
pISSN - 1079-9907
DOI - 10.1089/jir.2007.0120
Subject(s) - antiretroviral therapy , medicine , biology , human immunodeficiency virus (hiv) , virology , viral load
Intermittent administration of interleukin-2 (IL-2) to human immunodeficiency virus (HIV)- infected patients on antiretroviral therapy (ART) is capable of inducing significant increases in CD4 T cell counts as a result of increased T cell survival and decreased cell turnover. However, its role in the setting of ART interruptions (STI) is less well characterized. We sought to compare the effect of continuous (C) versus intermittent (P) ART on CD4 responses in patients undergoing IL-2 therapy.