Open AccessPilot Study of Caffeine Abstinence for Control of Chronic Glucose in Type 2 Diabetes
Author(s) -
James D. Lane,
Alex J. Lane,
Richard S. Surwit,
Cynthia M. Kuhn,
Mark N. Feinglos
Publication year - 2012
Publication title -
journal of caffeine research
Language(s) - English
Resource type - Journals
eISSN - 2156-5783
pISSN - 2156-5368
DOI - 10.1089/jcr.2012.0003
Subject(s) - abstinence , caffeine , type 2 diabetes , medicine , diabetes mellitus , endocrinology , physiology , psychiatry
BACKGROUND: A growing body of evidence suggests that caffeinated beverages may impair chronic glucose control in type 2 diabetes. This pilot study tested the chronic effects of caffeine abstinence on glucose control in type 2 diabetic patients who were daily coffee drinkers. METHODS: Twelve coffee drinkers (six males) with established type 2 diabetes participated. Seven (five males) completed 3 months of total caffeine abstinence. Measures of chronic glucose control, long-term (hemoglobin A1c [HbA1c]) and short-term (1,5-anhydroglucitol [1,5-AG]), were collected at baseline and during follow-up. Abstinence was established by diaries confirmed by saliva caffeine assays. RESULTS: Abstinence produced significant decreases in HbA1c and increases in 1,5-AG, both indicating improvements in chronic glucose control. Fasting glucose and insulin did not change, nor were changes in body weight observed. CONCLUSIONS: Although preliminary, these results suggest that caffeine abstinence may be beneficial for patients with type 2 diabetes. This hypothesis should be confirmed in larger controlled clinical trials.