Open AccessMohs Defect Repair with Dehydrated Human Amnion/Chorion Membrane
Author(s) -
Julia Toman,
Georgina M. Michael,
Oliver J. Wisco,
J. R. Adams,
Brandon Hubbs
Publication year - 2022
Publication title -
facial plastic surgery and aesthetic medicine
Language(s) - English
Resource type - Journals
eISSN - 2689-3622
pISSN - 2689-3614
DOI - 10.1089/fpsam.2021.0167
Subject(s) - cosmesis , medicine , surgery , basal cell carcinoma , population , amnion , skin cancer , basal cell , cancer , pathology , pregnancy , fetus , environmental health , biology , genetics
Importance: Reconstructing cosmetically sensitive defects in an aging population undergoing multiple Mohs micrographic surgeries (MMS) may be addressed with alternatives to surgery. Objective: Patients undergoing MMS with defect reconstruction in visually prominent areas receiving placental allograft were compared with traditional autologous tissue-based procedures-flaps and full-thickness skin grafts (FTSG). Design, Setting, and Participants: This retrospective case-control study evaluated patients who underwent MMS for removal of a basal or squamous cell carcinoma with same-day repair. Main Outcomes and Measures: The primary endpoint was the incidence and comparison of postoperative morbidity. Risk for developing medical or cosmetic sequelae was determined through multivariate logistic regression. Results: The study population consisted of 143 propensity score-matched pairs ( n = 286) with moderate- to high-risk defects on the face, head, and neck. Compared with autologous tissue, placental allograft cases were associated with significantly lower risk for infection ( p = 0.004), poor scar cosmesis ( p < 0.0001), scar revision ( p < 0.0001), or reoperation ( p = 0.0007). Conclusions and Relevance: Postoperative complication rates for placental reconstructions did not exceed those demonstrated by autologous tissue counterparts, indicating this is a safe alternative to flap and FTSG in cosmetically sensitive repairs.