Open AccessT Helper 9 Cells: A New Player in Immune-Related Diseases
Author(s) -
Jing Chen,
Lian Guan,
Lin Tang,
Shiming Liu,
Yue Zhou,
Chao Chen,
Zhisong He,
Lin Xu
Publication year - 2019
Publication title -
dna and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 77
eISSN - 1557-7430
pISSN - 1044-5498
DOI - 10.1089/dna.2019.4729
Subject(s) - biology , interleukin 9 , transcription factor , cytokine , immune system , immunology , t helper cell , microbiology and biotechnology , interleukin , cancer research , t cell , genetics , gene
The helper T cell 9 (Thelper-9, Th9), as a functional subgroup of CD4 + T cells, was first discovered in 2008. Th9 cells expressed transcription factor PU.1 and cytokine interleukin-9 (IL-9) characteristically. Recent researches have shown that the differentiation of Th9 cells was coregulated by cytokine transforming growth factor β, IL-4, and various transcription factors. Th9 cells, as a new player, played an important role in various immune-related diseases, including tumors, inflammatory diseases, parasite infection, and other diseases. In this article, we summarize the related research progress and discuss the possible prospect.